Journal article
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype
MAR Ferreira, MC Matheson, CS Tang, R Granell, W Ang, J Hui, AK Kiefer, DL Duffy, S Baltic, P Danoy, M Bui, L Price, PD Sly, N Eriksson, PA Madden, MJ Abramson, PG Holt, AC Heath, M Hunter, B Musk Show all
Journal of Allergy and Clinical Immunology | Published : 2014
Abstract
Background To date, no genome-wide association study (GWAS) has considered the combined phenotype of asthma with hay fever. Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma without hay fever. Objective We sought to perform a GWAS of asthma with hay fever to identify variants associated with having both diseases. Methods We performed a meta-analysis of GWASs comparing persons with both physician-diagnosed asthma and hay fever (n = 6,685) with persons with neither disease (n = 14,091). Results At genome-wide significance, we identified 11 independent variants associated with the risk of h..
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Awarded by Cystic Fibrosis Foundation
Funding Acknowledgements
Supported by the Australian National Health and Medical Research Council (NHMRC; grants 241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498, 613627, 403981, and 003209); the Australian Research Council (grants A7960034, A79906588, A79801419, DP0770096, DP0212016, and DP0343921); the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254); the US National Institutes of Health (grants AA07728, AA07535, AA10248, AA11998, AA13320, AA13321, AA13326, AA14041, AA17688, DA12854, and MH66206); Asthma Foundations in Tasmania, Queensland, and Victoria; the Clifford Craig Trust in Northern Tasmania; the Lew Carty Foundation; the Royal Hobart Research Foundation; the University of Melbourne; the Great Wine Estates of the Margaret River region of Western Australia; the University of Western Australia (UWA); Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; the Telethon Institute for Child Health Research; the Women and Infants Research Foundation; the Canadian Institutes of Health Research (MOP-82893); and the National Heart, Lung, and Blood Institute of the National Institutes of Health under grant no. 1R43HL115873-01.